M Pavel - summary


Mariana Pavel, PhD - University of Cambridge - 2016

Title: Actin cytoskeleton modulators reveal novel roles for autophagy in health and disease




Publications (updated May 2017)

/P1/ Avraham Ashkenazi, Carla F. Bento, Thomas Ricketts, Mariella Vicinanza, Farah Siddiqi, Mariana Pavel, Ferdinando Squitieri, Maarten C. Hardenberg, Sara Imarisio, Fiona M. Menzies, and David C. Rubinsztein. Polyglutamine tracts regulate beclin 1-dependent autophagy, Nature 545: 108-111 (2017); doi:10.1038/nature22078.


/P2/ Fiona Menzies*, Angeleen Fleming*, Andrea Caricasole*, Carla Bento*, Steven Andrews*, Avraham Ashkenazi*, Jens Fullgrabe*, Anne Jackson*, Maria Jimenez-Sanchez*, Cansu Karabiyik*, Floriana Licitra*, Ana LopezRamirez*, Mariana Pavel*, Claudia Puri*, Maurizio Renna*, Thoma Ricketts*, Lars Schlotawa*, Mariella Vicinanza*, Hyeran Won*, Ye Zhu*, John Skidmore*, and David C. Rubinztein. Autophagy in neuronal health and disease, Neuron 93(5): 1015-1034 (2017); doi: 10.1016/j.neuron.2017.01.022; * denotes equal contribution.


/P3/ Mariana Pavel, Sara Imarisio, Fiona M. Menzies, Maria Jimenez-Sanchez, Farah H. Siddiqi, Xiaoting Wu, Maurizio Renna, Cahir J O’Kane, Damian C. Crowther, David C. Rubinsztein. CCT complex restricts neuropathogenic protein aggregation via autophagy, Nature Communications 7:13821 (2016); doi: 10.1038/ncomms13821.


/P4/ Mariana Pavel and David C. Rubinsztein, Mammalian autophagy and the plasma membrane (State-of-the-Art review), FEBS Journal, October 2016; doi:10.1111/febs.13931.


/P5/ Xiaoting Wu, Angeleen Fleming, Thomas Ricketts, Mariana Pavel, Herbert Virgin, Fiona M. Menzies, David C. Rubinsztein. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis, Nature Communications 7:10533 (2016); doi:10.1038/ncomms10533.


/P6/ Mariana Pavel, Radu Tanasa, Alexandru Stancu. Magnetic trap effects on nanowire’s dynamics within micro-capillary vessels, Microfluidics and Nanofluidics 10:579 (2011); doi:10.1007/s10404-010-0691-3.


/P7/ Mariana Pavel, Alexandru Stancu. Ferromagnetic nanoparticles dose based on tumor size in magnetic fluid hyperthermia cancer therapy, IEEE Transactions on Magnetics 45(11), 5251-5254 (2009) doi:10.1109/TMAG.2009.2031076

/P8/ Mariana Pavel, Alexandru Stancu. Study of the optimum injection sites for a multiple metastases region in cancer therapy by using MFH, IEEE Transactions on Magnetics 45(10), 4825-4828 (2009) doi:10.1109/TMAG.2009.2024543

/P9/ Mariana Pavel, George Gradinariu, Alexandru Stancu, A study of the optimum dose of ferromagnetic nanoparticles suitable for cancer therapy using magnetic fluid hyperthermia, IEEE Transactions on Magnetics 44(11), 3205-3208 (2008); doi:10.1109/TMAG.2008.2001661.



Book chapter


Mariana Pavel, David C. Rubinsztein. Autophagy upregulation as a therapeutic strategy for neurodegenerative diseases. Book: Antitumor potential and other emerging medicinal properties of natural compounds. Editors: Evandro Fei Fang and Tzi Bun Ng. 2013, pp 227-238 (ISBN: 978-94-007-6213-8 (Print) 978-94-007-6214-5 (Online) ).