Mariana Pavel, PhD - University of Cambridge - 2016
Title: Actin cytoskeleton modulators reveal novel roles for autophagy in health and disease
Summary
Publications (updated May 2017)
/P1/ Avraham Ashkenazi, Carla F. Bento, Thomas Ricketts, Mariella Vicinanza, Farah Siddiqi, Mariana Pavel, Ferdinando Squitieri, Maarten C. Hardenberg, Sara Imarisio, Fiona M. Menzies, and David C. Rubinsztein. Polyglutamine tracts regulate beclin 1-dependent autophagy, Nature 545: 108-111 (2017); doi:10.1038/nature22078.
/P2/ Fiona Menzies*, Angeleen Fleming*, Andrea Caricasole*, Carla Bento*, Steven Andrews*, Avraham Ashkenazi*, Jens Fullgrabe*, Anne Jackson*, Maria Jimenez-Sanchez*, Cansu Karabiyik*, Floriana Licitra*, Ana LopezRamirez*, Mariana Pavel*, Claudia Puri*, Maurizio Renna*, Thoma Ricketts*, Lars Schlotawa*, Mariella Vicinanza*, Hyeran Won*, Ye Zhu*, John Skidmore*, and David C. Rubinztein. Autophagy in neuronal health and disease, Neuron 93(5): 1015-1034 (2017); doi: 10.1016/j.neuron.2017.01.022; * denotes equal contribution.
/P3/ Mariana Pavel, Sara Imarisio, Fiona M. Menzies, Maria Jimenez-Sanchez, Farah H. Siddiqi, Xiaoting Wu, Maurizio Renna, Cahir J O’Kane, Damian C. Crowther, David C. Rubinsztein. CCT complex restricts neuropathogenic protein aggregation via autophagy, Nature Communications 7:13821 (2016); doi: 10.1038/ncomms13821.
/P4/ Mariana Pavel and David C. Rubinsztein, Mammalian autophagy and the plasma membrane (State-of-the-Art review), FEBS Journal, October 2016; doi:10.1111/febs.13931.
/P5/ Xiaoting Wu, Angeleen Fleming, Thomas Ricketts, Mariana Pavel, Herbert Virgin, Fiona M. Menzies, David C. Rubinsztein. Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis, Nature Communications 7:10533 (2016); doi:10.1038/ncomms10533.
/P6/ Mariana Pavel, Radu Tanasa, Alexandru Stancu. Magnetic trap effects on nanowire’s dynamics within micro-capillary vessels, Microfluidics and Nanofluidics 10:579 (2011); doi:10.1007/s10404-010-0691-3.
/P7/ Mariana Pavel, Alexandru Stancu. Ferromagnetic nanoparticles dose based on tumor size in magnetic fluid hyperthermia cancer therapy, IEEE Transactions on Magnetics 45(11), 5251-5254 (2009) doi:10.1109/TMAG.2009.2031076
/P8/ Mariana Pavel, Alexandru Stancu. Study of the optimum injection sites for a multiple metastases region in cancer therapy by using MFH, IEEE Transactions on Magnetics 45(10), 4825-4828 (2009) doi:10.1109/TMAG.2009.2024543
/P9/ Mariana Pavel, George Gradinariu, Alexandru Stancu, A study of the optimum dose of ferromagnetic nanoparticles suitable for cancer therapy using magnetic fluid hyperthermia, IEEE Transactions on Magnetics 44(11), 3205-3208 (2008); doi:10.1109/TMAG.2008.2001661.
Book chapter
Mariana Pavel, David C. Rubinsztein. Autophagy upregulation as a therapeutic strategy for neurodegenerative diseases. Book: Antitumor potential and other emerging medicinal properties of natural compounds. Editors: Evandro Fei Fang and Tzi Bun Ng. 2013, pp 227-238 (ISBN: 978-94-007-6213-8 (Print) 978-94-007-6214-5 (Online) ).
Professor of Physics
(Electromagnetism, Magnetism, Computational Physics)
Ph.D. in Physics (Magnetism, Scientific Adviser: Prof. Constantin PAPUSOI)
- Director CARPATH Center of Excellence in Scientific Research (physics)
- Director AMON Interdisciplinary Platform
- Chair of IEEE Magnetics Society – Romania Section
- IEEE Senior Member, Administrative Committee member for IEEE MagSoc (2015-2017)
- Associate Editor — IEEE Magnetics Letters
- Editor-in-Chief — Journal of Advanced Research in Physics
- Editor-in-Chief — Revista Stiintifica V. Adamachi – Serie Noua
Publications
- >280 published ISI articles; >1700 independent citations; h=25
Research Grants
- >4 MEURO in scientific grants
Previous activities
- Head of Department (2000-2006)
- Vice-president of the National Commission for the evaluation of Open and Distance Learning programs – Commission 14 CNEAA 2000-2006
- Member of the Commission for the National Research Strategy 2009-2013
- Chair of the Solid State Division of the Romanian Physical Society (2009-2013)
- Member of IEEE Magnetics Society Administrative Committee (elected member) (2011-2013)
- Member of IEEE Magnetics Society Technical Committee (2006-2013)
Honours
- 2004 — Knight of the Order Merit in Education (Romanian Ministry of Education)
- 2010 — "Stefan Procopiu" Romanian National Academy Award
Ph.D. Students (finalized theses)
- Ion Dan BORCIA, Dorin CIMPOEŞU, Cristian ENĂCHESCU, Claudiu VERDEŞ, Petronel POSTOLACHE, Cristina CIOMAGA, Radu TANASĂ, Dan RICINSCHI, Cristina OLARIU, Aurelian ROTARU, Ilie BODALE, Iulian PETRILA, Irina URSACHI, Ovidiu CHISCAN, Cristian ROTARESCU, Costin DOBROTĂ, Eugen ONICIUC, Ciprian PINZARU, Alin LUNGU, Mihai NICA
Research
Visit Publons/ResearchID: https://publons.com/researcher/2887714/alexandru-stancu/
Education
- Habilitation in Physics in 2014 (Contributions to modeling and simulation of physical processes with hysteresis)
- D.Sc. 'Magna cum Laude' in Physics (magnetism) in 2001. (The Effect of the Reversible Magnetisation Processes on the Magnetisation Mechanism of the Ferromagnetic Particulate System)
- M.Sc. in Physics in 1996
- B.Sc. in Technical Physics 1995
Experience
- 1996-1998 — Research assistant within the Department of Electricity and Physical Electronics, Faculty of Physics, "Alexandru Ioan Cuza" University.
- 1998-2001 — Teaching assistant within the Department of Electricity and Physical Electronics, Faculty of Physics, "Alexandru Ioan Cuza" University. While completing the PhD research activity, the job involved the conducting of laboratories and seminars.
- 2001-2007 — Lecturer within the Department of Electricity and Physical Electronics, Faculty of Physics, "Alexandru Ioan Cuza" University.
- 2007-2019 — Associate Professor within the Department of Solid State Physics, Faculty of Physics, "Alexandru Ioan Cuza" University.
- since 2019 — Professor within the Department of Physics, Faculty of Physics, "Alexandru Ioan Cuza" University.
Courses and labs
- Parallel programming (MSc level)
- Electricity and Magnetism (BSc level)
- Introduction to the Modelling of Physical Processes (BSc level)
- The Modelling of the Physical Processes (MSc level)
- Using Computers in the Teaching of Physics (both BSc and MSc levels)
- Multimedia Technologies (BSc level)
- ICT in Education (BSc level)
- Databases (I and II) (BSc level)
- Programming languages (I and II) (BSc level)
Visits
- 2022 — visiting professor, Washington and Lee University, Lexington, VA, USA.
- 2018 — visiting professor, Washington and Lee University, Lexington, VA, USA.
- 2018 — visiting researcher, IMEC, Leuven, Belgium.
- 2006 — Research fellow at the Institute of Science and Technology for Ceramics, Faenza and University of Genoa, both in Italy, funded in the framework of the COST 525 programme.
- 2000-2001 — 6 months research grant at the Centre of Materials Science, University of Central Lancashire, Preston, UK, funded by the Romanian Government.
- June 2000 — Summer School: NATO-ASI Magnetic Storage Systems Beyond 2000, Rhodes, Greece, organised by George Washington University, USA.
- 1999 — 5 months research grant at Technische Universitat, Vienna, Austria, funded by the Socrates Program (more information) (http://info.tuwien.ac.at/wde/text/99-1.html - broken link!).
- 1996 — 3 months research grant at the Laboratoire de Magnetisme et D'Optique, Universite de Versailles, France, funded by the Tempus Program.
- June 1995 — Summer School: Magnetisme des Nanoparticules et des Materiaux Nanophases, Iasi, Romania.
Scientific techniques and skils
- Knowledge regarding general experimental techniques and principles.
- Experimental vector magnetic measuring techniques acquired during the 6 months research project at the Centre for Materials Science, University of Lancashire, Preston, UK, under the supervision of professor Philip R. Bissell
- Thorough modelling and simulations knowledge and experience obtained in operating with vector Preisach-type models and Landau-Lifshitz systems to describe magnetic particulate systems. Recent experience with finite element method and with parallel programing obtained while implementing and using magpar: http://www.magpar.net/ and mumax http://mumax.github.io/
- Experience in programming, numerical techniques and experimental data analysis (C/C++, Python, Julia, Fortran, Java, Maple, MatLab, Qt).
- Other programming skils (Databases - MySQL/PHP, Visual Basic, HTML, 2D and 3D Graphics - Java 3D, OpenGL).
- Advanced numerical analysis (CUDA, OpenMPI and other parallelization frameworks, VNI-IMSL, GSL).
Other educational activities
- 1999 — Graduate of the "LOLA - Learn About Open Learning" course organised by the Heriot-Watt University from Edinburgh, UK and PHARE Program.
- Founding member of the Iasi Distance Education Study Centre, established within the PHARE Multi-Country Programme for Distance Education.
- Co-author of the textbooks "Modern Educational Technologies" and "Programs for Windows".
- since 2010 — Different ARACIS Certifications.
Professional organisations memberships
- since 2020 — President of the Physics Comittee of the Romanian National Council for Scientific Research (CNCS)
- 2016 — Member of the Romanian National Council for Scientific Research (CNCS)
- since 2011 — Senior IEEE Member.
- since 2005 — Secretary of the IEEE Magnetics Society Chapter of the Romania Section;
- since 2002 — Member of the IEEE - Magnetics Society
Education
- D.Sc. Physics (magnetism of nano-structures) in 2007 with distinction “Summa cum laude” (Thesis: Contributions to the study of magnetization processes in structured particulate ferromagnetic media) @ "Alexandru Ioan Cuza" University, Romania
- D.Sc. Physics (molecular magnetism – photoswitchable materials) in 2006 with distinction “Tres honorable avec felicitations du jury” (Thesis: Analysis and study of the hysteretic properties in thermo- piezo- and photo-switchable spin-transition compounds) @ Versailles Saint Quentin en Yvelines University, France
- M.Sc. in Physics in 2004
- B.Sc. in Physics in 2002
Awards and Scholarships
- 2008 — Prize for best research group from a Romanian University awarded by National Authority for Scientific Research (ANCS - Romania) at the “Top of excellence in research” contest
- December 2007 — Excellence prize for outstanding contributions in physics of magnetic nanostructures from National science and art foundation of Romanian Academy
- 2007 — European Doctorate in Molecular Magnetism diploma awarded by MAGMANet (Molecular Approach to Nanomagnets and Multifunctional Materials – FP6 NoE 515767-2)
- 2007 — Cotutelle thesis award - “Alexandru Ioan Cuza” University of Iasi
- 2005-2006 — Eiffel Doctorate Scholarship - for top-level PhD students (international competition, funded by French Minster of External Affairs through EGIDE)
- 2004-2005 — Romanian Government Scholarship
- December 2003 — CARPATH Excellence Prize awarded by the Centre for Applied Research in Physics and Advanced TecHnologies, Romania
Experience
- since 2013 — Lecturer within the Department of Physics, Faculty of Physics, "Alexandru Ioan Cuza" University
- 2014-2016 — Research associate @ Department of Engineering, University of Cambridge, UK (Project title: “Micromechanical measurements in living embryos”)
- 2010-2012 — Postdoctoral fellow @ Department of Physics, ”Alexandru Ioan Cuza” University of Iasi, RO (Project title: “Switching in highly correlated hysteretic systems" - CORELSYS)
- 2008-2013 — Assistant Professor within the Department of Physics, Faculty of Physics, "Alexandru Ioan Cuza" University
- 2005-2008 — Teaching Assistant within the Department of Physics, Faculty of Physics, "Alexandru Ioan Cuza" University
Courses and labs
- Physics and Technology of Magnetic Materials (MSc level)
- Electricity and Magnetism (BSc level)
- Introduction to the Modelling of Physical Processes (BSc level)
- The Modelling of the Physical Processes (MSc level)
- Data Acquisitions and Processing Systems (BSc level)
- Virtual Instrumentation (MSc level)
- Theoretical and Numerical Micromagnetism (MSc level)
- Information Technologies (BSc level)
- Programming languages (BSc level)
- Data Acquisitions Systems (MSc level)
Visits
- 2011 — University Francois Rabelais Tours, France (Dr Beatrice Negulescu)
- 2009 — National High Magnetic Field Laboratory (MagLab) - Florida State University, Tallahassee, Florida (Prof Irinel Chiorescu)
- 2007-2011 — University of Versailles, France (Prof Jorge Linares)
- 2007, 2009 — Advanced Materials Research Institute (AMRI) - University of New Orleans, New Orleans, Louisiana (Prof Leonard Spinu)
- 2007 — University of Central Florida, Orlando, Florida (Prof James J. Hickman)
- 2007 — University of Geneva, Geneva, Switzerland (Prof Andreas Hauser)
Scientific techniques and skils
- Knowledge regarding general experimental techniques and principles.
- Experimental magnetic characterization: VSM / AGM, QD-MPMS XL (low field profiling, photomagnetism, pressure cell)
- Optical characterization: transmission spectroscopy, reflectivity under pressure, SPIM
- Cryogenic closed circuit systems technology: optical cryostat (2.8 – 300 K), Cryomech’s 12 liters per day liquid helium plant as part of helium recovery solution for MPMS
- Instrumentation development: magnetic tweezers for in vivo studies, pressure FORC optical detection platform
- Experience in programming, numerical techniques and experimental data analysis (C/C++, Fortran, Maple, COMSOL Multiphysics, LabView, Python, Qt, OpenCV)
Professional organisations memberships
- since 2006 — Member of the IEEE - Magnetics Society
Research
- 31 papers in the domain of magnetism and magnetic materials, spin transition materials, modeling and simulation
